Using your keyboard, press down and hold the Command + Ctrl + Power keys until your screen goes blank. If you're using a wireless mouse, check that you have new batteries or that the mouse is fully charged. When your mouse disappears on your Mac, it's time first to check the basics. No matter the reason, we'll get to the bottom with these helpful tips and tricks. Third-party apps are causing interference. It's one of those really frustrating issues that you hope you'll never encounter here's a couple of reasons why your mouse pointer disappears on your Mac. Why does my mouse keep disappearing on Mac? So, let's take a look at why this happens, and review some troubleshooting tips to solve it when your Mac mouse disappears. While it’s an extraordinary situation, it can indicate other underlying problems, like your Mac being infected with adware. Have you noticed the cursor disappear on your Mac? Some apps change the appearance of the pointer so it’s the first logical explanation.